Halina Offner Selected Research

Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

4/2022	Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs.
1/2022	"Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
12/2021	Brief report: Enhanced DRα1-mMOG-35-55 treatment of severe EAE in MIF-1-deficient male mice.
10/2019	Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE.
1/2019	Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct.
10/2018	Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells.
1/2017	Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.
4/2016	Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.
10/2015	Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice.
8/2015	IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice.

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Halina Offner Research Topics

Disease

66	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2022 - 01/2002
49	Multiple Sclerosis 01/2022 - 10/2002
33	Stroke (Strokes) 01/2021 - 05/2006
25	Inflammation (Inflammations) 01/2021 - 03/2002
18	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 07/2002
13	Infarction (Infarctions) 01/2020 - 04/2010
11	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2020 - 05/2006
6	Neuroinflammatory Diseases 01/2021 - 06/2007
6	Ischemic Stroke 12/2019 - 10/2014
5	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 06/2010
5	Experimental Arthritis 06/2012 - 02/2004
4	Brain Ischemia (Cerebral Ischemia) 07/2017 - 05/2006
4	Encephalomyelitis (Myeloencephalitis) 01/2017 - 03/2002
4	Atrophy 09/2013 - 06/2006
4	Disease Progression 06/2010 - 02/2003
4	Rheumatoid Arthritis 06/2009 - 05/2004
3	Brain Injuries (Brain Injury) 10/2017 - 11/2007
3	Central Nervous System Diseases (CNS Diseases) 08/2015 - 09/2013
3	Arthritis (Polyarthritis) 06/2009 - 12/2003
2	Ischemia 01/2017 - 09/2013
2	Brain Infarction 01/2017 - 01/2014
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2011 - 09/2008
1	Neuroblastoma 04/2022
1	Body Weight (Weight, Body) 01/2022
1	Nervous System Diseases (Neurological Disorders) 12/2021
1	Astrocytoma (Pilocytic Astrocytoma) 12/2021
1	Dementia (Dementias) 12/2021
1	Brain Neoplasms (Brain Tumor) 12/2021
1	Alzheimer Disease (Alzheimer's Disease) 12/2021
1	Weight Loss (Weight Reduction) 01/2020
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019

Drug/Important Bio-Agent (IBA)

29	Estrogens (Estrogen)FDA Link 10/2019 - 03/2002
28	Peptides (Polypeptides)IBA 10/2017 - 07/2003
28	LigandsIBA 10/2015 - 07/2003
26	T-Cell Antigen Receptors (T-Cell Receptor)IBA 02/2015 - 01/2002
19	CytokinesIBA 01/2021 - 09/2002
11	Estradiol (Delestrogen)FDA LinkGeneric 10/2015 - 03/2002
9	AntigensIBA 03/2012 - 10/2004
8	ChemokinesIBA 01/2021 - 03/2002
8	Therapeutic UsesIBA 01/2020 - 07/2003
7	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2017 - 02/2005
7	Estrogen Receptor alphaIBA 04/2010 - 10/2003
6	Interleukin-10 (Interleukin 10)IBA 10/2019 - 09/2013
6	HLA-DR2 Antigen (HLA DR2 Antigen)IBA 10/2014 - 07/2003
6	Myelin Basic ProteinIBA 05/2010 - 01/2003
5	Interleukin-6 (Interleukin 6)IBA 01/2020 - 09/2005
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2009 - 03/2002
4	Macrophage Migration-Inhibitory FactorsIBA 01/2022 - 07/2017
4	Interleukin-17 (Interleukin 17)IBA 06/2011 - 11/2007
4	Proteins (Proteins, Gene)FDA Link 01/2008 - 09/2005
3	Biomarkers (Surrogate Marker)IBA 04/2022 - 07/2017
3	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 10/2014
3	Immunologic Factors (Immunomodulators)IBA 01/2018 - 04/2010
3	Messenger RNA (mRNA)IBA 07/2017 - 05/2006
3	AntibodiesIBA 10/2015 - 06/2010
3	HLA-DRB1 Chains (HLA DRB1)IBA 02/2015 - 09/2004
3	SteroidsIBA 05/2013 - 05/2010
3	Myelin-Oligodendrocyte GlycoproteinIBA 03/2012 - 07/2003
3	Ethinyl Estradiol (Estinyl)FDA LinkGeneric 04/2010 - 02/2003
3	Hormones (Hormone)IBA 04/2010 - 01/2004
3	Estrogen ReceptorsIBA 01/2010 - 03/2008
3	Histamine (Histamine Dihydrochloride)FDA Link 09/2008 - 03/2004
2	dopachrome isomeraseIBA 12/2021 - 10/2017
2	Neutralizing AntibodiesIBA 12/2019 - 01/2014
2	HLA Antigens (Human Leukocyte Antigens)IBA 10/2017 - 12/2015
2	Neuroprotective AgentsIBA 07/2017 - 04/2010
2	Estriol (Epiestriol)IBA 01/2017 - 05/2013
2	salicylhydroxamic acid (SHAM)IBA 01/2017 - 01/2016
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2012 - 03/2008
2	Complement System Proteins (Complement)IBA 09/2011 - 09/2003
2	Histocompatibility Antigens Class IIIBA 05/2011 - 01/2008
2	InterferonsIBA 03/2011 - 10/2009
2	CollagenIBA 11/2010 - 06/2009
2	Collagen Type II (Type II Collagen)IBA 01/2008 - 05/2005
2	myelin proteolipid protein (139-151)IBA 09/2006 - 09/2005
2	Interleukin-2 (IL2)IBA 05/2006 - 03/2004
2	EpitopesIBA 10/2004 - 02/2003
2	5-androstene-16-fluoro-17-oneIBA 02/2004 - 09/2002
1	NeurotoxinsIBA 04/2022
1	GAP-43 Protein (GAP 43 Protein)IBA 04/2022
1	tyrphostin A9IBA 04/2022
1	MSH Release-Inhibiting Hormone (MIF-I)IBA 01/2022
1	Adenosine Monophosphate (AMP)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	GenisteinIBA 01/2022
1	ProgranulinsIBA 12/2021
1	Pharmaceutical PreparationsIBA 01/2020
1	DRhQIBA 01/2020
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2019
1	Cell Surface ReceptorsIBA 01/2019
1	Neomycin FDA LinkGeneric 10/2018
1	Vancomycin FDA LinkGeneric 10/2018
1	Metronidazole (Metric)FDA LinkGeneric 10/2018

Therapy/Procedure

34	Therapeutics 01/2021 - 01/2003
3	Splenectomy 07/2018 - 01/2015
2	Thrombectomy 01/2018 - 07/2017
2	Aftercare (After-Treatment) 08/2015 - 09/2005
2	Immunotherapy 10/2014 - 01/2014
1	Oral Administration 04/2022
1	Transplantation 01/2021